abstract：UNLABELLED:Type I collagen is widely applied as a biomaterial for tissue regeneration. In the extracellular matrix, collagen provides strength but not elasticity under large deformations, a characteristic crucial for dynamic organs and generally imparted by elastic fibers. In this study, a methodology is described to i...

journal_title：Acta biomaterialia

authors： Versteegden LR,Hoogenkamp HR,Lomme RM,van Goor H,Tiemessen DM,Geutjes PJ,Oosterwijk E,Feitz WF,Hafmans TG,Verdonschot N,Daamen WF,van Kuppevelt TH

更新日期：2016-10-15 00:00:00

abstract：UNLABELLED:Although attenuated malaria parasitized red blood cells (pRBCs) are promising vaccine candidates, their application in humans may be restricted for ethical and regulatory reasons. Therefore, we developed an organic microparticle-based delivery platform as a whole parasite malaria-antigen carrier to mimic pRB...

journal_title：Acta biomaterialia

authors： Giddam AK,Reiman JM,Zaman M,Skwarczynski M,Toth I,Good MF

更新日期：2016-10-15 00:00:00

abstract：UNLABELLED:We have developed a novel hydroxyapatite (HAp)-coated double-network (DN) hydrogel (HAp/DN gel). The purpose of this study was to determine details of the cell and tissue responses around the implanted HAp/DN gel and to determine how quickly and strongly the HAp/DN gel bonds to the bone in a rabbit osteochon...

journal_title：Acta biomaterialia

authors： Wada S,Kitamura N,Nonoyama T,Kiyama R,Kurokawa T,Gong JP,Yasuda K

更新日期：2016-10-15 00:00:00

abstract：UNLABELLED:The vitreous humor of the eye is a biological hydrogel principally composed of collagen fibers interspersed with hyaluronic acid. Certain pathological conditions necessitate its removal and replacement. Current substitutes, like silicone oils and perfluorocarbons, are not biomimetic and have known complicati...

journal_title：Acta biomaterialia

authors： Santhanam S,Liang J,Struckhoff J,Hamilton PD,Ravi N

更新日期：2016-10-01 00:00:00

abstract：UNLABELLED:We show with laboratory experiments that self-assembled mineral tube formation involving precipitation around a templating jet of fluid - a mechanism well-known in the physical sciences from the tubular growth of so-called chemical gardens - functions with carbonates, and we analyse the microstructures and c...

journal_title：Acta biomaterialia

authors： Cardoso SSS,Cartwright JHE,Checa AG,Sainz-Díaz CI

更新日期：2016-10-01 00:00:00

abstract：UNLABELLED:Advanced titanium (Ti) based bone implant with both angiogenesis and osteogenesis stimulating activities for enhanced clinical performance is stringently needed. In the present work, TiO2/calcium-phosphate (TCP) coatings on Ti doped with cobalt (Co) of various amounts (designated as C2-TCP, C7-TCP, and C13-T...

journal_title：Acta biomaterialia

authors： Zhou J,Zhao L

更新日期：2016-10-01 00:00:00

abstract：UNLABELLED:Chondrocyte dedifferentiation presents a major barrier in engineering functional cartilage constructs. To mitigate the effects of dedifferentiation, this study employed a post-expansion aggregate culture step to enhance the chondrogenic phenotype of passaged articular chondrocytes (ACs) before their integrat...

journal_title：Acta biomaterialia

authors： Huang BJ,Hu JC,Athanasiou KA

更新日期：2016-10-01 00:00:00

abstract：UNLABELLED:Fluorescence microscopy and spectroscopy techniques are commonly used to investigate complex and interacting biological systems (e.g. proteins and nanoparticles in living cells), since these techniques can explore intracellular dynamics with high time resolution at the nanoscale. Here we extended one of the ...

journal_title：Acta biomaterialia

authors： Digiacomo L,Digman MA,Gratton E,Caracciolo G

更新日期：2016-09-15 00:00:00

abstract：UNLABELLED:Sodium polyphosphate is a linear polymer formed from phosphate units linked together by sharing oxygen atoms. Addition of calcium to a solution of sodium polyphosphate results in phase separation and formation of a polyphosphate coacervate best described as a polymeric rich viscoelastic material. Polyphospha...

journal_title：Acta biomaterialia

authors： Momeni A,Filiaggi MJ

更新日期：2016-09-01 00:00:00

abstract：UNLABELLED:Poly(3,4-ethylenedioxythiophenes) (PEDOT) have been extensively explored as materials for biomedical implants such as biosensors, tissue engineering scaffolds and microelectronic devices. Considerable effort has been made to incorporate biologically active molecules into the conducting polymer films in order...

journal_title：Acta biomaterialia

authors： Bhagwat N,Murray RE,Shah SI,Kiick KL,Martin DC

更新日期：2016-09-01 00:00:00

abstract：UNLABELLED:The design of polymeric nanoparticles for gene therapy requires engineering of polymer structure to overcome multiple barriers, including prolonged colloidal stability during formulation and application. Poly(β-amino ester)s (PBAEs) have been shown effective as polymeric vectors for intracellular DNA deliver...

journal_title：Acta biomaterialia

authors： Kim J,Kang Y,Tzeng SY,Green JJ

更新日期：2016-09-01 00:00:00

abstract：UNLABELLED:Humans make high levels of antibody to carbohydrates with terminal galactose α 1,3 galactose (Gal) modifications. This Gal antigen is widely expressed in other mammals and is present on an array of current animal derived biomedical devices including bioprosthetic heart valves. There is growing interest in us...

journal_title：Acta biomaterialia

authors： McGregor C,Byrne G,Rahmani B,Chisari E,Kyriakopoulou K,Burriesci G

更新日期：2016-09-01 00:00:00

abstract：UNLABELLED:Epithelial cellular heterogeneity has been observed in pathological tissues with abnormal matrix stiffness and cells cultured on rigid substrates. However, it remains unclear how matrix stiffness influences cellular heterogeneity formation in multi-cellular population. Here, we demonstrated that cellular het...

journal_title：Acta biomaterialia

authors： Wang B,Qin P,Zhao H,Xia T,Wang J,Liu L,Zhu L,Xu J,Huang C,Shi Y,Du Y

更新日期：2016-09-01 00:00:00

abstract：UNLABELLED:Natural amino acids are zwitterionic molecules and the good biocompatibility promises them potential candidates as anti-fouling materials. Here, we developed a new method to functionalize silica nanoparticles with a natural amino acid-based anti-fouling layer. Amino acids were covalently immobilized on 3-ami...

journal_title：Acta biomaterialia

authors： Wang H,Cheng F,Shen W,Cheng G,Zhao J,Peng W,Qu J

更新日期：2016-08-01 00:00:00

abstract：UNLABELLED:The present study serves three main functions. First, it presents a novel random copolymer, made of octadecyl acrylate hydrophobic blocks and 2-(dimethylamino)ethyl methacrylate hydrophilic groups, and it zwitterionic form. Second, random copolymer and zwitterionic random copolymer, OmDn and Z-OmDn, are used...

journal_title：Acta biomaterialia

authors： Venault A,Ye CC,Lin YC,Tsai CW,Jhong JF,Ruaan RC,Higuchi A,Chinnathambi A,Ho HT,Chang Y

更新日期：2016-08-01 00:00:00

abstract：UNLABELLED:Antifouling polymers have wide applications in biomedical engineering and marine industry. Recently, zwitterionic materials have been reported as promising candidates for antifouling applications, while strong hydration is believed to be the key antifouling mechanism. Zwitterionic materials can be designed w...

journal_title：Acta biomaterialia

authors： Leng C,Sun S,Zhang K,Jiang S,Chen Z

更新日期：2016-08-01 00:00:00

abstract：UNLABELLED:Novel photo-reactive phospholipid polymers were synthesized for use in the preparation of nonfouling surfaces with protein conjugation capacity. Poly[2-methacryloyloxyethyl phosphorylcholine (MPC)-ran-N-methacryloyl-(l)-tyrosinemethylester (MAT)] (P(MPC/MAT)) was synthesized by conventional radical polymeriz...

journal_title：Acta biomaterialia

authors： Tanaka M,Iwasaki Y

更新日期：2016-08-01 00:00:00

abstract：UNLABELLED:A synergistic effect of biochemical and mechanical cues emanating from the extracellular matrix (ECM) on inducing malignant transformation of epithelial cells has been observed recently. However, the effect of quantitative changes in biochemical stimuli on cell phenotype, without changes in ECM component and...

journal_title：Acta biomaterialia

authors： Marlar S,Abdellatef SA,Nakanishi J

更新日期：2016-07-15 00:00:00

abstract：UNLABELLED:This study aims to present a new intelligent polymeric nano-system used for combining chemotherapy with non-viral gene therapy against human cancers. An amphiphilic copolymer synthesized through the conjugation of low molecular weight polyethyleneimine (LMw-PEI) and poly(ε-caprolactone) (PCL) via a bio-cleav...

journal_title：Acta biomaterialia

authors： Davoodi P,Srinivasan MP,Wang CH

更新日期：2016-07-15 00:00:00

abstract：UNLABELLED:The development of scaffolds for bone filling of large defects requires an understanding of angiogenesis and vascular guidance, which are crucial processes for bone formation and healing. There are few investigations on the ability of a scaffold to support blood vessel guidance and it this is of great import...

journal_title：Acta biomaterialia

authors： Magnaudeix A,Usseglio J,Lasgorceix M,Lalloue F,Damia C,Brie J,Pascaud-Mathieu P,Champion E

更新日期：2016-07-01 00:00:00

abstract：UNLABELLED:ECM-based materials are appealing for tissue engineering strategies because they may promote stem cell recruitment, cell infiltration, and cell differentiation without the need to supplement with additional biological factors. Cartilage ECM has recently shown potential to be chondroinductive, particularly in...

journal_title：Acta biomaterialia

authors： Beck EC,Barragan M,Tadros MH,Gehrke SH,Detamore MS

更新日期：2016-07-01 00:00:00

abstract：UNLABELLED:Tissue engineering strategies, such as cellularized scaffolds approaches, have been explored for cartilage replacement. The challenge, however, remains to produce a cartilaginous tissue incorporating functional chondrocytes and being large and thick enough to be compatible with the replacement of articular d...

journal_title：Acta biomaterialia

authors： Luciani N,Du V,Gazeau F,Richert A,Letourneur D,Le Visage C,Wilhelm C

更新日期：2016-06-01 00:00:00

abstract：UNLABELLED:Recently, photodynamic therapy (PDT) is one of the new clinical options by generating cytotoxic reactive oxygen species (ROS) to kill cancer cells. However, the optical approach of PDT is limited by tissue penetration depth of visible light. In this study, we propose that a ROS-enhanced nanoparticle, hafnium...

journal_title：Acta biomaterialia

authors： Chen MH,Hanagata N,Ikoma T,Huang JY,Li KY,Lin CP,Lin FH

更新日期：2016-06-01 00:00:00

abstract：UNLABELLED:Rapid vascularization of bone graft substitutes upon implantation is one of the most important challenges to overcome in order to achieve successful regeneration of large, critical-size bone defects. One strategy for stimulating vascularization during the regeneration process is to create a hypoxic microenvi...

journal_title：Acta biomaterialia

authors： Tahmasebi Birgani Z,Fennema E,Gijbels MJ,de Boer J,van Blitterswijk CA,Habibovic P

更新日期：2016-05-01 00:00:00

abstract：UNLABELLED:To use siRNA (small interfering RNA) for gene therapy, a gene delivery system is often necessary to overcome several challenging requirements including rapid excretion, low stability in blood serum, non-specific accumulation in tissues, poor cellular uptake and inefficient intracellular release. Active and/o...

journal_title：Acta biomaterialia

authors： Zhi D,Zhao Y,Cui S,Chen H,Zhang S

更新日期：2016-05-01 00:00:00

abstract：UNLABELLED:A new a biocompatible Ti42Zr40Ta3Si15 (atomic %) porous bulk glassy alloy was produced by combination of rapid solidification and powder metallurgy techniques. Amorphous alloy ribbons were fabricated by melt spinning, i.e. extremely fast quenching the molten alloy with 10(6)K/s from T=1973K down to room temp...

journal_title：Acta biomaterialia

authors： Nicoara M,Raduta A,Parthiban R,Locovei C,Eckert J,Stoica M

更新日期：2016-05-01 00:00:00

abstract：UNLABELLED:To improve the ocular bioavailability of the model drug of pirenoxine sodium (PRN), organic-inorganic hybrid nanocomposites including layered double hydroxides (LDH) and chitosan derivatives (chitosan-glutathione (CG), chitosan-glutathione-valine (CG-V) and chitosan-glutathione-valine-valine (CG-VV)) were de...

journal_title：Acta biomaterialia

authors： Xu T,Zhang J,Chi H,Cao F

更新日期：2016-05-01 00:00:00

abstract：UNLABELLED:By means of appropriate cell type and scaffold, tissue-engineering approaches aim to construct grafts for cartilage repair. Pluripotent stem cells especially induced pluripotent stem cells (iPSCs) are of promising cell candidates due to the pluripotent plasticity and abundant cell source. We explored three d...

journal_title：Acta biomaterialia

authors： He P,Fu J,Wang DA

更新日期：2016-04-15 00:00:00

abstract：UNLABELLED:Cellular microenvironments present cells with multiple stimuli, including not only soluble biochemical and insoluble matrix cues but also mechanical factors. Biomaterial array platforms have been used to combinatorially and efficiently probe and define two-dimensional (2D) and 3D microenvironmental cues to g...

journal_title：Acta biomaterialia

authors： Liu H,Usprech J,Sun Y,Simmons CA

更新日期：2016-04-01 00:00:00

abstract：UNLABELLED:The novel concept of modifying and enhancing the properties of existing functional micelles through self-complementary interactions has significant potential. In this study, a practical approach to living polymerization of functionalized thermoresponsive monomers enabled the incorporation of self-constituted...

journal_title：Acta biomaterialia

authors： Cheng CC,Chang FC,Kao WY,Hwang SM,Liao LC,Chang YJ,Liang MC,Chen JK,Lee DJ

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Mechanical characteristics of vascular tissue may play a role in different arterial pathologies, which, amongst others, requires robust constitutive descriptions to capture the vessel wall's anisotropic and non-linear properties.Specifically, the complex 3D network of collagen and its interaction with other ...

journal_title：Acta biomaterialia

authors： Sáez P,García A,Peña E,Gasser TC,Martínez MA

更新日期：2016-03-01 00:00:00

abstract：UNLABELLED:We have developed two-step process that uses sequential vitamin B2-induced UVA crosslinking and thermal gelation to solidify decellularized extracellular matrix (dECM) bioink; this process enables tailoring of mechanical properties of 3D-printed bioconstructs. This is the first evaluation of vitamin B2 for u...

journal_title：Acta biomaterialia

authors： Jang J,Kim TG,Kim BS,Kim SW,Kwon SM,Cho DW

更新日期：2016-03-01 00:00:00

abstract：UNLABELLED:Medical device-associated infections are a multi-billion dollar burden for the worldwide healthcare systems. The modification of medical devices with non-leaching coatings capable of killing microorganisms on contact is one of the strategies being investigated to prevent microorganism colonization. Here we d...

journal_title：Acta biomaterialia

authors： Rai A,Pinto S,Evangelista MB,Gil H,Kallip S,Ferreira MG,Ferreira L

更新日期：2016-03-01 00:00:00

abstract：UNLABELLED:Porous titanium implants are widely used in dental, orthopaedic and otorhinolaryngology fields to improve implant integration to host tissue. A possible step further to improve the integration with the host is the incorporation of autologous cells in porous titanium structures via cell-laden hydrogels. Fast ...

journal_title：Acta biomaterialia

authors： Koenig G,Ozcelik H,Haesler L,Cihova M,Ciftci S,Dupret-Bories A,Debry C,Stelzle M,Lavalle P,Vrana NE

更新日期：2016-03-01 00:00:00

abstract：UNLABELLED:Myofibroblasts are critical for connective tissue remodeling and wound healing since they can close wound beds and shape tissues rapidly by generating high traction forces and secreting abundant extracellular matrix proteins and matrix metalloproteinases. However, their presence in excessive numbers is assoc...

journal_title：Acta biomaterialia

authors： Kural MH,Billiar KL

更新日期：2016-03-01 00:00:00

abstract：UNLABELLED:With improvements in oral health and an overall increase in quality of life, the percentage of fully or largely dentate seniors is increasing. Understanding the effects of aging on the mechanical properties of teeth is essential to the maintenance of lifelong oral health. In this investigation the effects of...

journal_title：Acta biomaterialia

authors： Yahyazadehfar M,Zhang D,Arola D

更新日期：2016-03-01 00:00:00

abstract：UNLABELLED:Quercetin (3,3',4',5,7-pentahydroxy-flavone) is a flavonoid known for its pharmacological activities, which include antioxidant and anti-inflammatory properties, as well as possible beneficial action on diseases involving bone loss. In this work, we explored the possibility to functionalize hydroxyapatite (H...

journal_title：Acta biomaterialia

authors： Forte L,Torricelli P,Boanini E,Gazzano M,Rubini K,Fini M,Bigi A

更新日期：2016-03-01 00:00:00

abstract：UNLABELLED:Recent studies reveal many biomaterial vaccine carriers are able to activate immunostimulatory pathways, even in the absence of other immune signals. How the changing properties of polymers during biodegradation impact this intrinsic immunogenicity is not well studied, yet this information could contribute t...

journal_title：Acta biomaterialia

authors： Andorko JI,Hess KL,Pineault KG,Jewell CM

更新日期：2016-03-01 00:00:00

abstract：UNLABELLED:Biomimetic materials were developed to regulate stem cell behaviour. We have analyzed the influence of polycaprolactone (PCL) films, functionalized with adhesive peptides derived from fibronectin (pFibro) or bone sialoprotein (pBSP), on the response of murine multipotent C3H10T1/2 cells to bone morphogenetic...

journal_title：Acta biomaterialia

authors： Beauvais S,Drevelle O,Lauzon MA,Daviau A,Faucheux N

更新日期：2016-02-01 00:00:00

abstract：UNLABELLED:Tissue cells are known to respond to the stiffness of the polymer substrate on which they are grown. It has been suggested that material stiffness influences the composition of the protein layer that adsorbs to the material surface, which affects subsequent cell behavior. Previously, the stiffness of a bioma...

journal_title：Acta biomaterialia

authors： Vyner MC,Amsden BG

更新日期：2016-02-01 00:00:00